Prophecy/Relias RN Pharmacology A Practice Test

A potassium level of 3.0 is considered hypokalemic, which significantly increases the risk of digoxin toxicity. Digoxin works by increasing the force of heart contractions and regulating heart rhythm. However, potassium plays a critical role in maintaining the balance of electrical activity in heart cells.

When potassium levels are low, the risk of digoxin toxicity rises because potassium and digoxin compete for the same binding sites on Na+/K+ ATPase pumps in cardiac cells. With less potassium available, digoxin can more easily bind to these sites, exaggerating its effects and potentially leading to toxic symptoms such as arrhythmias, nausea, vomiting, and visual disturbances.

Patients taking digoxin should have their potassium levels monitored closely. Hypokalemia not only increases the risk of toxicity but could also lead to serious complications, including cardiac dysrhythmias. Therefore, managing the potassium levels is essential to maintaining the safety and effectiveness of digoxin therapy.